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1 Institute of Life Science, College of Medicine, Swansea University, Swansea SA2 8PP, UK 2 Centre for Integrative Brain Research, Seattle Children’s Hospital, Seattle, WA 98101, USA 3 Department of Neuroradiology, Frenchay Hospital, Bristol BS16 1LE, UK 4 Wales Epilepsy Research Network (WERN), College of Medicine, Swansea University, Swansea SA2 8PP, UK 5 Institute of Medical Genetics, University Hospital of Wales, Cardiff CF14 4XW, UK 6 Center for Human Genetics and Department of Human Genetics, University of Regensburg, 93053 Regensburg, Germany 7 Department of Radiology, Great Ormond Street Hospital for Children, London W1W 5AH, UK 8 Departments of Paediatrics and Genetics, University of North Carolina, Chapel Hill, NC 27514, USA 9 Department of Paediatric Neurology, Great Ormond Street Hospital for Children, London W1W 5AH, UK 10 Institute of Human Genetics, University Medical Centre, Hamburg-Eppendorf, 20246 Hamburg, Germany 11 Department of Clinical Genetics, Royal Devon and Exeter NHS Foundation Trust, Exeter EX1 2ED, UK